Op-molb130065 1720..1728
نویسندگان
چکیده
Since its first release in 2001 as mainly a software package for phylogenetic analysis, data analysis for molecular biology and evolution (DAMBE) has gained many new functions that may be classified into six categories: 1) sequence retrieval, editing, manipulation, and conversion among more than 20 standard sequence formats including MEGA, NEXUS, PHYLIP, GenBank, and the new NeXML format for interoperability, 2) motif characterization and discovery functions such as position weight matrix and Gibbs sampler, 3) descriptive genomic analysis tools with improved versions of codon adaptation index, effective number of codons, protein isoelectric point profiling, RNA and protein secondary structure prediction and calculation of minimum folding energy, and genomic skew plots with optimized window size, 4) molecular phylogenetics including sequence alignment, testing substitution saturation, distance-based, maximum parsimony, and maximum-likelihood methods for tree reconstructions, testing the molecular clock hypothesis with either a phylogeny or with relative-rate tests, dating gene duplication and speciation events, choosing the best-fit substitution models, and estimating rate heterogeneity over sites, 5) phylogeny-based comparative methods for continuous and discrete variables, and 6) graphic functions including secondary structure display, optimized skew plot, hydrophobicity plot, and many other plots of amino acid properties along a protein sequence, tree display and drawing by dragging nodes to each other, and visual searching of the maximum parsimony tree. DAMBE features a graphic, user-friendly, and intuitive interface and is freely available from http://dambe.bio.uottawa.ca (last accessed April 16, 2013).
منابع مشابه
Supernova OH ( 1720 MHz ) Masers in Sgr A East , W 28 and G 359 . 1 - 0 . 5
A new class of OH (1720 MHz) masers unaccompanied by main-line transitions have recently been discovered (Frail, Goss and Slysh 1994). These masers lie at the interface between supernova remnants (SNRs) interacting with molecular clouds. We discuss three new aspects of SN masers found in the direction toward the Galactic center: (i) the detection of a new –130 kms OH (1720 MHz) maser in the sou...
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From origins in their heartlands in Easter Ross, clan Munro produced no fewer than three distinct medical dynasties, all descended from Hugh Munro, 9th Baron Foulis (c1352-1425), 12th chief of the clan. This paper describes what we believe to be a unique family of related medical dynasties which were influential in Edinburgh, London and the Scottish Highlands. It sets out in detail the family g...
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